Some couples are healthy, and conventional inspections have not found in organic or functional reproductive system diseases, but they cannot have childbirth.Modern studies have found that this is likely to be related to the immune response of both parties.
Immune response is an epidemic prevention response to foreign objects that enter the body.If the foreign body is antigen (such as protein, polypeptide, etc.), the body will generate the corresponding antibody according to the characteristics of the antigen to neutralize this antigen to achieve the purpose of removing foreign objects in the body.This is the antigen antibody response, that is, immune response.If a certain immune response in the human body affects fertility, immune infertility will occur.
There are two types of immune responses affecting fertility: one is the self -immunity of the man; the other is the same type of immunity of the woman.
The self -immunity is the overflowing reproductive tract of male sperm and sperm into its own surrounding tissue, causing an immune response to their bodies, producing corresponding antibody substances in the body, and affecting the vitality of sperm.
Human semen consists of two major components: sperm and sperm pulp. These two ingredients contain many egg acetic quality. These proteins can become an antigen.However, because there is a structure called "blood test barrier" in the testicles, sperm can be protected in the male reproductive tract to prevent immune cells in the blood from contacting sperm, so immune response will not produce.On the other hand, there is an immunosuppressive factors in the sperm pulp that can inhibit immune response, so the immune response will not occur after the sperm enters the female reproductive tract.
However, when there are damage, inflammation, and obstruction factors, the "blood test barrier" is damaged or immunosuppressive dysfunction, resulting in sperm overflowing the genital tract, entering the surrounding tissue into the blood, becoming a foreign body to play an antigen.The immune system that stimulates the body produces a antibody against its sperm to neutralize.Therefore, men's immune infertility is the result of anti -sperm antibody and sperm.
It can be seen that the factors that lead to immune infertility may come from the man, or the woman, or the men and women.The main cause is the inflammation, damage, and menstrual sexual intercourse and unclean life of men and women.
(Editor in charge: Internship Zhang Yiwen)
