There are many causes of male infertility. The disorder caused by genetic factors is an important factor that causes male infertility.Studies have shown that about 7%to 15%of men with primary and spermatozoa have a micro -deficiency in Y chromosomes.Therefore, patients with non -sperm or minor sperm should be tested by azf micro -lack.
Human Y chromosomes have four important areas, and their lack is closely related to male infertility. These four areas are AZFA, AZFB, AZFC and AZFD.AZFA is less lacking, accounting for about 1%to 5%of the lack, but the lack of the most serious consequences. Patients are manifested as only to support cell syndrome, the testicular volume is reduced, and no sperm generation. At presentMethods; patients with lack of AZFB are manifested by the lack of spermatogenesis and epithelial cells after decomposition and division. The process of spermatogenesis is blocked at the stages of sperm cells and has no sperm production. The lack of AZFC gene is the most common cause of sperm growth disorders.65%of the lack of lack can be manifested as no spermosis, or it can be used as a sperm count, but it is accompanied by abnormal sperm form;The form is abnormal.
The micro -lack of Y chromosome may cause abnormal function of sperm, which leads to male infertility.The detection of AZF micro -lack can make some clinical cause of unknown or less sperm or less, and the patient's clear cause, which provides a basis for clinical diagnosis and treatment.
(Editor in charge: Internship Zhang Yiwen)
