The number of male infertility patients is closely related to immune factors. Immune infertility is mainly caused by sperm antigen.
First, semen contains a variety of antigens, and there is a "blood test barrier" in the normal testicular structure, so that the antigen in the semen cannot enter the blood system. When the barrier is destroyed, the antigen stimulating the body's immune system in the semen generates antibodies and combines it with it.The immune response destroys the normal form and function of the sperm, which causes immune infertility.
2. At present, there have been antigen material slurry antigens on the neutral and sperm cells. The types of sperm antigens are determined by immunohic electricity.Serum protein, such as albumin, iron protein, etc.Some antigens collide with other tissues. If the milk iron protein that exists in milk and saliva, this milk iron protein is also adsorbed to sperm. It is difficult to remove even if washed and became one of the main sperm antigen.
Third, the name of the sperm antigen is very chaotic. In addition to iron protein and emulsion iron protein, it is recognized as brightened aminotinase, prostate acidic phosphatase, prefabricated albumin, albumin, etc.Plane, hyaluronase, top protease, and protein hydraulic enzyme inhibitors have antigenicity.The body's immune system has the function of protecting its own antigen, identification and exclusion of foreign antigen.Under normal circumstances, due to the balance and coordination of the body's immune system, immune damage will not cause an antigen in its own antigen. Whether the external antigen can stimulate the body to produce an effective immune status and no adult agent.The same antibody stimulation stimulates different bodys, and even the same antigen stimulates the same body at different times, which can produce different immune effects and cause male immune infertility.
(Editor in charge: Internship Zhang Yiwen)
