In recent years, there have been many studies on men's contraceptives.Such contraceptives generally inhibit the production of sperm, reduce the number of sperm, and achieve young sperm or even no sperm and cannot conceive.
To understand the principle of the role of men's contraceptives, we must first understand the process of sperm.The tube of the sperm tube in the testicles is covered with 5 to 8 layers of cells, which supports cells and spermocytes, also known as raw essential epithelium.Support cells arranged on the base film arranged in the sperm tube. The top extends to the lumen. It has the function of supporting, nutrition, and protecting spermatogonic cells at all levels. It may also have the function of regulating intermedium cells.Differentiated, from spermocytes, primary sperm cells, secondary sperm cells, sperm cells, and sperm finally forms sperm, arranged layer by layer from the base to the lumen direction.
Each primary sperm cells can be split into, four sperm cells, which are attached to the concave nests that support the top of the cell to obtain nutrients, and experience the perverted maturity process, and develop into sperm.Sperm sperm is a continuous process. It is like an endless relay race. It is produced at all times, and the sperm formed daily can reach hundreds of millions of sperm.The developmental sperm enters the epididymis with the testicles.The process of spermatogenesis is mainly involved and regulated by the hypothalamus, pituitary and gonadotropin.
Male contraceptives can play through different channels:
(1) The corresponding antibodies that promote follicle hormones and lutein toiletin are used to block the role of this type of hormone.However, because these two hormones contain the same A sub -unit, and the same as the A sub -unit of thyroid hormones, the effect of antibodies can not achieve unnecessary side effects when the antibody does not achieve a specific antipathy against this hormone.
(2) Selective suppression of spermatic epithelial drugs, glycol, is a scholar in my country that first discovered its anti-fertility effect and conducted a large number of research and clinical trials in China.The study has attracted international attention.It is a kind of male oral contraceptive, cheap, simple, but also has certain side effects.No matter what kind of male contraceptives have similar disadvantages, that is, the effect is slow, because the above drugs have no killing effect on the generated sperm; and because the sperm process requires a certain time, after the drug is stopped, the fertility function is functioning, and the fertility function is functional.Recovery is also slow.
(3) Use autologous hormones, such as using testosterone alone, or combined with progesterone, to inhibit the hydrogen hormone and inhibit the sperm effect by negative feedback.The regular injection of testosterone can achieve an anti -fertility effect, and it can be restored after stopping the drug. It is a promising male contraceptive pill.The above drugs are interfered with the spermatogenesis process by inhibiting the hypothalamus, one pituitary gland axis.Drug prices are expensive, inconvenient, and at the same time inhibit the function of testicular intercostal cells, so that the level of ketone is reduced, and sexual desires are reduced or there are still further research solutions.Although testosterone also inhibits the function of interstitial cells. Because it has an alternative effect, it does not affect sexual function and has good prospects.
(4) Long -term use of a large amount of gonadotropin to release hormones, and the abolition of the secretion of the pituitary gonadotropin (promoting follicle hormone and luteinin) by decreased the decrease in the adjustment of the bonus.
(Editor in charge: Doudou)
