The incidence of iconic veins in young men is higher. According to the literature reported in 1971, at the physical examination of 1072 students 6-19 years old, 188 young people with 6-9 years have no iconic veins.And 136 of the 831 young people aged 10-19 have the left sperm veins, accounting for 16.12%.Moreover, it is not uncommon for the infertility caused by the iconic vein song. As early as 1880, a surgeon in the UK first proposed that the iconic veins can cause male infertility.There are the following aspects:
1. Teste endocrine disorders
When varicose veins are tension, it can damage the testicular interstitial cells and affect the secretion of testosterone.It also reduces the function of testicular synthesis testosterone and interferes with the occurrence of sperm.
Second, the pressure in the iconic vein increases
The increased venous pressure hinders testicular metabolism, the accumulation of metabolic waste, which hinders the production of sperm.
Third, testes local hypoxia and pH changes
Variable blood flow is blocked, which affects the blood circulation of the testicles, leading to the accumulation of CO2 in the local blood, changing the pH value, interfered with normal metabolism of the testicles, and affecting sperm production.
Fourth, the material reflux in the adrenal and adrenal veins
The blood in the left renal vein, the vein of the left sperm in the left sperm vein when the sperm vein is tension, and the metabolites of the adrenal glands such as cortisol, catecholamine, prostaglandin, and 5-hydroxyline will enter the testicles against the testicular tissue and kill the sperm, Significantly affect the mobility of sperm.
V. Increase testicular temperature
For patients with intravenous veins, the temperature of the testicles increases by 0.6 ° C-0.8 ° C than the average of normal people.Zorqnuioff measures the average testicular temperature of normal people's left testicles of 32.2 ° C and 31.8 ° C on the right.The iconic veins are 1 ° C higher than normal people, and the right side is 1.3 ° C.Those with obvious temperatures, decreased sperm, decreased significantly.
Six, pathological changes
The sperm electron microscope observation of the sperm vein patients found that sperm mature disorders (top bodies diffusion, rupture or reduction of spherical shape, nuclear chromatin loose, empty bubbles appear in the nuclear);, Top expansion, blurred edges, mitochondria arrangement disorders, missing or accumulating groups in the middle section); cell membrane structure changes (bulging nodules, decreased membrane protein particles, uneven distribution).It shows that the development of sperm cells is blocked, and some of them cannot be mature, and deformities can occur even if they are mature, leading to infertility.
Seven, testicular blood flow dynamics changes
When the spermatic vein is tension, the testicles and veins are damaged, leading to blood circulation disorders, changes in blood flow dynamics, and changes in cell microcirculation.Transformation or falling off.
8. Immune response
A series of pathophysiological changes caused by varicocele can change the immune function of the body.Wu Mingzhang and others found that the iconic iconic sealing tubular membrane and small -quality small blood vessels were found in immune complex deposition.In addition, there are asab blood and semen in the sperm veins in the sperm veins. Asab can interfere with the maturity process of sperm and sperm, reduce the number of sperm, and Asab can also adhere to the sperm membrane, causing the sperm form and the shape of the sperm and the form of the sperm and the form of the spermFunction is abnormal.
The cause of the iconic veins that cause infertility is not just the dysfunction caused by the single factors caused by testicular damage, but the result of the synergy of multiple factors.
(Editor in charge: zero -degree warm)
