The abnormal white blood cell content in semen can affect the sperm density, survival rate, malformation rate, forward exercise, low osmosis swelling rate, increased viscosity increase, etc., which reduces the comprehensive quality of semen, which will cause reduction of fertility or male infertility.
The mechanism of male infertility caused by abnormal leukocyte content in semen: Sperm and white blood cells are directly contacted. Active macrophages and neutrophils can produce and release a large amount of active oxygen through swallowing (mainly include superal oxygen ions, hydrogen peroxide, and Hydroxyl free radicals, etc.), oxygen free radicals can attack sperm cell membrane, causing lipid peroxidation to damage sperm cell membrane, and toxic the sperm.In addition, the products of white blood cells, such as leukemin, interferon, tumor necrosis factor, etc., can affect the maturity and function of sperm by inhibiting the synthesis of cell protein and chemical.In addition, the infiltration of white blood cells in epididymal, prostate epithelium, etc. can cause dysfunction of these accessories glands, which affects the maturity and operation of sperm in the reproductive tract.Studies have shown that the positive rate of anti -sperm antibodies in semen with abnormal leukocyte content in semen has a significant increase in anti -sperm antibodies, which shows that abnormal leukocyte content in semen can also cause immune male infertility.
In summary, abnormal white blood cell content in semen will not only reduce the quality of semen, but also cause anti -sperm antibodies in the patient's body, which will cause reduced fertility or male infertility.
(Editor in charge: Internship Zhang Yiwen)
