There are many causes of male infertility. Studies have found that genetic mutations and infertility are closely related. The specific content is as follows:
Cystic fibrosis cross -membrane regulating protein gene
A cystic fibrosis cross -membrane regulating protein coding is a chloride channel protein related to cystic fibrosis, which plays an important role in maintaining the micro -environment, early embryo formation, and the function of vollarization.The survey shows that only 2%-3%of patients have normal fertility among cystic fibrous degenerative male patients.Gene mutations are not the main decisive factor of male sperm -generating disorders, but may be related to mature sperm and sperm.
Arogen receptor gene
Arogen is necessary for sperm. Allrogens must be played through therogen receptor. Single nucleotide wrong mutations are the most common types ofrogen receptor gene mutations. Some male infertilityPatients are caused by this.Studies have found that in patients with nearly 30%of severe spermatozoa and antibody patients, the nucleotide dynamic mutations of the 1st exogenous sub -emergence of therogen receptor gene were detected.
Mitochondria
Sperm swimming must be sufficient energy. As a "energy factory" of cells, mitochondria are closely related to male infertility.Mitigation of mitochondrial genes can lead to reduced sperm vitality and eventually cause male infertility.Although sperm malformed patients can produce a normal number of sperm, more than 50%of sperm swimming ability decreases.
(Editor in charge: Internship Zhang Yiwen)
