The pathogenesis of infertility caused by antibody antibodies involves various conditions and links of the fertilization process, and it is not conducive to fertilized eggs to bed, which affects the ending of pregnancy.Mainly related to the following factors: that is, damaged sperm function, decreased sperm exercise ability, sperm's cervical mucus, fertilized disorders, hyperthyroid phagocytes, and bed disorders.
1. Damage to testicular essence function
The autoimmune response caused by sperm immunity first affects the sperm function of the testicular.Men's infertility patients have abnormal sperm -proof, severe ejaculation, and (or) sperm abnormalities.For testicular biopsy, common sex cells are lack of sexual cells, and the function of making essence is low or terminated.Using guinea pigs or big white mice to organize immunohistosus with a testosckic tissue, can induce decoction is a good example.
Second, sperm exercise ability decreases
In vitro experiments have proven that when the exercise sperm is added to antibodies, sperm will occur due to the effects of agglutonin, braking factor, and sperm cytotoxic antibodies, or lose the ability of exercise.The same results will be obtained by experiments.Therefore, anti -sperm antibodies will affect the transportation of sperm in women's reproductive tracts. In addition, the result of antigen antibody reactions can also cause sperm material metabolic disorders.High -efficiency antibodies can cause sperm to die or lose fertilization. Even if sperm can still be fertilized under the conditions of low -cost antibodies, such fertilized eggs will die during development.
Third, sperm is blocked through cervical mucus
(1) The antibody antibody in the blood moves in the cervical mucus (CM). If there is a sufficient amount of supplement, once it is combined with the uplifting sperm, the sperm will be in a braking state.The abdomen of the pot cannot be fertilized.
(2) The FC end of the antibody IGG has a strong non -specific adhesion and the glucose in CM. The antibody F (AB) 2 after the sticky antibody is free.Insufficient body volume and no braking effect, but because of capturing sperm antibodies, its FC end is adhesive to CM, resulting in the captured sperm cannot move forward, and can only be used as the original swing, so the sperm upward is also blocked.
(3) If there is an autoimmune antibody antibody in the male semen, the sperm surface antigen is first combined with the F (AB) 2 of the antibody to make the end of the FC.CM glycoprotein bonding, sperm is also hindered in CM.
The above analysis has been proven in animal experiments. Clinically, women with antibody antibodies in the blood have appeared abnormalities after sexual intercourse.most.
(Editor in charge: Internship Liu Suqiong)
