Among women in childcare, repeated abortion or embryo stopping development occurs around us, and there is a tendency to increase.While these patients are actively looking for women's factors, doctors of gynecology or reproductive centers also recommend that patients' husbands come to the orrology clinic to find the men's pathogenic factors.This in the end is why?
Repeated abortion is also related to the development of embryo
The formation of embryos is developed by the man's sperm and the woman's eggs together. The factors of any party can cause repeated abortion and the embryo to stop developing.
So, which factors can cause repeated abortion?
1. Genetic factors
Including the abnormality of autonomous chromosomes and Y dyes.This is a clear reason for the women's abortion and embryo, which is why we need to check the chromosome.Humans contain 23 pairs of chromosomes, and chromosomes No. 1 to 22 are called autonomic chromosomes. The difference in chromosomal No. 23 determines the gender of men and women.It is reported that 22%to 61%of abortion embryos have chromosomal abnormalities.
2. Sperm DNA damage
Sperm quality is related to the development of fertilized eggs to the bubble period and implantation capacity. The gene -expressed gene can regulate the proliferation and invasion of nourishing layer cells and subsequent placenta proliferation.Sperm DNA integrity is extremely important for sperm interaction, fertilization, and early fertilized egg cracks.Studies have shown that RSA and embryo stop and sperm DNA damage have increased significantly.
3. Anti -sperm antibody
Normal men do not produce anti -sperm antibodies due to the protection of blood test barriers.Studies have shown that RAS men, their positive anti -sperm antibody positive rates are higher than normal men.Its possible mechanism: 体 antibody adhesion sperm surface causes sperm to condense each other and affects the movement of sperm; when the body activity in the sperm is high, it will also cause the medium attack response and damage the sperm;The vitality of the radiation crown is inhibited; the antigen point of the tie's membrane is closed to inhibit the adhesion and penetration of the sperm to the transparent band; ⑸ affects the binding of sperm and eggs;
4. Infection factors
At present, it is believed that the chlamydia (CT) reconcile 脲脲 primary (UU) infection is an important pathogen that causes RSA. The UU attached to the sperm surface can secrete neurotipidase. When entering the oval mother cells, the embryo will dieMistration; they can cause endometritis response, affect the regulation mechanism of the mother's immune system to protect the embryo, interfere with the embryo bed or damage the embryo in the growth and induce abortion;, Produce ASAB, which will affect the development of early embryos and cause miscarriage.In addition, the sperm DNA damage rate of patients with UU or CT patients is 3.2 times higher than the control group. After antibiotics, the DNA damage rate can be reduced.Of course, the infection of TORCH (eugenics) can also cause abortion and embryo.
(Editor in charge: Zheng Guisheng)
