Some recent findings on the impact of drugs on ejaculation have made us start to understand the possible neurological mechanism of premature ejaculation.For example, pseudo ephedrine, ephedrine, hydrochloride and other drugs can improve the activity of sympathetic nerves and promote male ejaculation with ejaculation disorders.Interestingly, there are reports that patients who are taking chloropyrazine will have orgasm related to yawn, and patients taking Flubuidin will have spontaneous orgasm with the increase in the dosage of the drug.These findings have led to the study of a large amount of delayed ejaculation drugs. The three main drugs are dopamine antagonists, antidepressants and antimiced drugs.
◆ Dopamine antagonist ◆
Such drugs, including anti -psychiatric drugs (also known as mental inhibitory drugs), can block dopamine receptors that can block the center.By observing the sexual excitement of ampamine (dopamine excitement), it can be antagonal by fluoroprine (dopamine receptor blockers in the center), and can also be antagonal by atypical dopamine receptor blockers sulfenidamineHowever, the fact that the fact that the dopamine receptor blocker that cannot be passed through the blood -brain barrier does not antagonize the fact that drugs have an effect on delay ejaculation.Dopamine antagonist shows a clear role in inhibiting ejaculation on humans or animals, including niomicit (anti -psychiatric drugs), metharoxylramine (tadpan vomiting), sulfenidine, fluoropyrine, and oxytocin.Antagonist, oxytocin.Other anti -psychiatric drugs that can delay ejaculation include chloropyrazine and sulidine. These two drugs can also block the receptor of adrenaline.
◆ Anti -depression drugs ◆
Anti-depression drugs are a new generation of delayed ejaculation drugs, which can improve the level of 5-hydrolytic (5-HT) in the human body.These drugs include 5-HT's removal of selective inhibitors (SSRIS) Fluividin, Shequlin and Parosdine.While blocking 5-HT, these drugs also have the effect of anti-choline energy.The rise of the 5-HT level is considered one of the mechanisms to suppress ejaculation.Old three -ring antidepressants also affect ejaculation.These drugs have the characteristics of sedation, anti-choline energy and antihistamines, and also hindered the re-intake of 5-HT.However, the obstacles of these drugs have less selectivity of the 5-HT re-intake, and their other characteristics may have a poor impact on patients' compliance.Among these drugs, chlorobylzide has a hindered effect on the re-intake of 5-HT and tormeal adrenaline.Chlorobylzide can improve the stimulating threshold of the genital site sensor, but there is no effect on the evolution of the sacrum or the arousal of the back side nerve body feel.Another three -ring antidepressant drug that suppress ejaculation is amparin forest, which has obvious anti -choline energy effects.
A recent study compares the effectiveness and safety of Freardin, Squlin, and chloropyrazine in the treatment of premature ejaculation.Lin can significantly improve the ejaculation incubation period in the vagina.Although there is no statistical support, the sexual satisfaction rate of patients with chlorobyrazine is higher than that of two other drugs.Therefore, in terms of efficacy, chlorobylzide is the most effective, but the incidence of sidelines is low.
◆ Anti -anxiety drugs ◆
Many of them are known to treat the phenolin zitzen anti-anxiety drugs that are used for extensive anxiety and anxiety. It has the effect of inhibiting ejaculation in some men. The mechanism may be to strengthen GABA (G-aminobutyric acid).These drugs include Liming Ning, Laurax, and Apzolun.However, their impact on ejaculation is not as common and obvious as other drugs (such as SSRIS). The comparison research shows that only less than 10%of men taking such drugs are delayed than before.
Tienone is an incomplete 5-HT agonist, which can improve the sexual function of patients with extensive anxiety.
◆ Other types of drugs ◆
Phenolfish:
It is reported that non-selective A-adrenaline receptor blockers phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenolic phenoica has the effect of inhibiting ejaculation.In the past, it was considered that ejaculation was dominated by the sympathetic nerves alone, but now it may be commonly disposed of in the sympathetic nerve and adsmine nervous system. Among them, the sympathetic nervous system is responsible for sending the semen to the prostate part of the urethra, and the sub -sympathetic nervous system is responsible for the transfer of semen.
Surface anesthetic:
Several reports described that through application surface anesthesia, it can reduce the local sensation and inhibit ejaculation.For example, benzakin and ground cloth (3%solution).Thirty minutes before sexual intercourse, 2.5 grams of Prucaine-Lidaaine ointment can improve the symptoms of 82%of patients with premature ejaculation.
Various drugs:
Other studies have shown that the blew eggplant alkaloids, one bromine camphor, levocyba and campyine have a certain effect in clinical practice.Patients with premature ejaculation have tried to use the therapy in the penis sponge body but not being promoted.
Because the high sensitivity of the penis is speculated that it is an important reason for premature ejaculation pathophysiology, we have developed a product called SS-Ointment Cream. It contains natural Chinese herbal medicine ingredients to reduce the high sensitivity of the penis andThere is no systemic complications such as dry or sleepy.In a two-blind, random, and multi-center clinical study of 106 patients who recently treated premature ejaculation with SS-Ointment, 82.2%of patients have been extended for more than 2 minutes (the control group is 10.3%), The sexual satisfaction rate of self-prosecution has also increased significantly (SS-Paste 82.2%, and the control group is 12.6%).In the future, premature premature ejaculation can be used to apply such surfactants in the future.
(Editor in charge: Internship Liu Suling)
