The recent discovery of the impact of drugs on ejaculation has made us start to learn about the possible neurological mechanism of premature ejaculation.For example, pseudo ephedrine, ephedrine, hydrochloric acid and other drugs can improve the activity of sympathetic nerves and improve male ejaculation with ejaculation disorders.Interestingly, there are reports that patients who are taking chlorobyrazine will have a yawnga orgasm, and patients taking Floshin will have spontaneous orgasm with the increase in the dose of the drug.
These findings have caused a large amount of research on a large amount of delayed ejaculation drugs. The three main drugs are dopamine antagonists, antidepressants and anti -anxiety drugs.
Dopamine antagonist
Such drugs, including anti -psychiatric drugs (also known as mental inhibitory drugs), can block dopamine receptors that can block the center.By observing the sexual excitement of ampamine (dopamine excitement), it can be antagonal by fluoroprine (dopamine receptor blockers in the center), and can also be antagonal by atypical dopamine receptor blockers sulfenidamineHowever, the fact that the fact that the dopamine receptor blocker that cannot be passed through the blood -brain barrier does not antagonize the fact that drugs have an effect on delay ejaculation.
Dopamine antagonist shows a clear role in inhibiting ejaculation on humans or animals, including niomicit (anti -psychiatric drugs), metharoxylramine (tadpan vomiting), sulfenidine, fluoropyrine, and oxytocin.Antagonist, oxytocin.Other anti -psychiatric drugs that can delay ejaculation include chloropyrazine and sulidazine. These two drugs can also block the receptor of the adnant renin.
Antidepressants
Anti-depression drugs are a new generation of delayed ejaculation drugs, which can improve the level of 5-hydrolytic (5-HT) in the human body.These drugs include 5-HT re-intake selective inhibitors (SSRIS) Flobidin, Shequlin and Parosdine.While blocking the 5-HT re-intake, these drugs also have the effect of anti-choline energy.The rise of the 5-HT level is considered one of the mechanisms to suppress ejaculation.
Old three -ring antidepressants also affect ejaculation.These drugs have the characteristics of sedation, anti-choline energy and antihistamines, and also hindered the re-intake of 5-HT.However, the obstacles of these drugs have less selectivity of 5-HT re-intake, and their other characteristics may have adverse effects on patients' compliance.Among these drugs, chlorobylzide has hindered 5-HT and re-intake of dehuminin.Chlorobylzide can improve the stimulating threshold of the genital site sensor, but there is no effect on the evolution of the sacrum or the arousal of the back side nerve body feel.
